Scientific journal
Fundamental research
ISSN 1812-7339
"Перечень" ВАК
ИФ РИНЦ = 1,674

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MEDICAL-BIOLOGICAL PROBLEMS OF ATHEROSCLEROSIS MODELING

Yuzhik E.I. 1 Lushnikova E.L. 1
1 Research Institute of Regional Pathology and Pathomorphology SD RAMS, Novosibirsk
Atherosclerosis is one of the most common diseases worldwide. It’s based on abnormalities in lipid metabolism leading to emergence of fatty streaks and fibrous plaques in arterial walls. Atherosclerosis affects the entire artery tree, but mostly larger, high-pressure vessels such as the coronary, renal, femoral, cerebral, and carotid arteries. These events result in decreased vascular lumen, thrombosis, and, finally, stroke or myocardial infarction. Inability to investigate human atherosclerosis can be overcomed by the usage of animals. A number of anatomic, physiological and behavioral risk factors for atherosclerosis can be investigated by experimental modeling. In this review we have analyzed various animal models of atherosclerosis. We pointed at the similarity of different animal models of atherosclerosis and human atheromatous plaques. It is known, that findings from animal models are difficult to interpret for human, and the area of any model applying is limited. In this review we emphasized at the species-specific features and the ability to achieve human-like injures by dietary modulation and pharmacological treatment in various models.
atherosclerosis
modeling diseases
animal models
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Рецензенты:

Селятицкая В.Г., д.б.н., профессор, зав. лабораторией эндокринологии Федерального государственного бюджетного учреждения «Научный центр клинической и экспериментальной медицины» Сибирского отделения РАМН, г. Новосибирск;

Любарский М.С., д.м.н., профессор, зав. отделом клинической морфологии и заместитель директора по научной работе ФГБУ «Научно-исследователь­ский институт клинической и экспериментальной лимфологии» Сибирского отделения РАМН, г. Новосибирск.