Scientific journal
Fundamental research
ISSN 1812-7339
"Перечень" ВАК
ИФ РИНЦ = 1,674

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SIGNALING MOLECULES AND ULCEROGENESIS IN THE ELDERLY

Stojakov A.M. 1 Ilnitski A.N. 2 Bessarabov V.I. 2 Zhernakova N.I. 3 Sovenko G.N. 3 Liutsko V.V. 3
1 «Your clinic» Medical Center, Moscow
2 «Gerontology» Research Medical Center, Moscow
3 Belgorod State University, Belgorod, Russia
The study investigated the signal characteristics of the molecular interactions in elderly people suffering from peptic ulcer disease. It is shown that with acute condition peptic ulcer IFN-α level was significantly higher in patients with Helicobacter pylori (HP) – associated peptic ulcer disease and in patients whose disease was not associated with the infection. The dependence of the level of IFN-α from the stage of disease and the association with HP-infection described. Found that levels of chemokines MCP-1 and NAF during exacerbation was significantly increased regardless of the HP-infection. The levels of selectin GMP-40 and ELAM-1 in peptic ulcer disease, regardless of its stage and the presence / absence of HP infection vary slightly and not significantly different from those in healthy subjects. It was concluded that increasing the concentration of the major signaling molecules (proinflammatory cytokines (IFN-α), chemokines (MCP-1 and NAF)) may be an indicator of the severity of ulcer disease in the elderly.
peptic ulcer disease
cytokines
chemokines
advanced age
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Рецензенты:

Иванова М.А., д.м.н., профессор-консультант медицинского центра «Ваша клиника», г. Москва;

Чеботарев П.А., д.м.н., доцент, заведующий кафедрой безопасности жизнедеятельности человека УО «Полоцкий государственный университет», г. Полоцк.