Scientific journal
Fundamental research
ISSN 1812-7339
"Перечень" ВАК
ИФ РИНЦ = 1,798

Personal portfolio
(submit article)

THE SYSTEM OF IL-6 AS A RISK FACTOR OF URGENT CRITICAL CONDITION DEVELOPMENT IN PATIENTS WITH ESSENTIAL HYPERTENSION

Radaeva O.A. 1, Novikova L.V. 2
1 Mordovian State N.P. Ogariov University
2 Mordovian State N.P. Ogariov University, Saransk
Objectives. We tested the hypothesis that serum interleukin-6 (IL-6) and its soluble receptor (sIL-6R) levels predict cardiovascular events in patients with in essential hypertension (ЕAН). Methods. We prospectively studied in 120 patients with II stage ЕAН (68 men and 52 women), 49,5±2,8 years of age. Serum IL-6 and sIL-6R levels were measured with an enzyme-linked immunosorbent assay. Results. During a median 5-year follow-up, 32 cardiovascular events occurred. Both total IL-6 and sIL-6R levels were direct associated with the risk of cardiovascular events. Patients in the 2 higher quartiles of IL-6 (≥18,2 pg /ml) had an increase risk of cardiovascular events compared with patients in the 2 lower quartiles (relative risk: 7, 95% confidence interval: 2,6 to 13,3). Patients in the 2 higher quartiles of IL-6 (≥18,2 pg /ml) had an increase risk of cardiovascular events compared with patients in the 2 lower quartiles (relative risk: 7, 95% confidence interval 2,6 to 13,3). Compared with the third quartile of serum sIL-6R levels (1739 - 1890 pg /ml), the relative risks the first-ever stroke and the myocardial infarction for patients with II stage ЕAН were as follows fourth quartile (1891 - 2218 pg /ml), 6 (95% confidence interval, 2,7 - 10). Conclusions. High serum interleukin-6 (IL-6) and its soluble receptor (sIL-6R) predicted a increased 5-year risk of cardiovascular events in patients with ЕAН.
essential hypertension
interleukin-6
soluble receptor
myocardial infarction
blood stroke

Рецензенты:

Потатуркина-Нестерова Н.И., д.м.н., профессор, зав. курсом микробиологии кафедры общей и клинической фармакологии, ФВПОУ ВПО «Ульяновский государственный университет», г. Ульяновск;

Карзакова Л.М., д.м.н., профессор, заведующая кафедрой госпитальной терапии № 2 медицинского факультета, ФВПОУ ВПО «Чувашский государственный университет имени И.Н. Ульянова», г. Чебоксары.

Библиографическая ссылка

Радаева О.А., Новикова Л.В. «СИСТЕМА ИНТЕРЛЕЙКИНА-6 КАК ФАКТОР РИСКА РАЗВИТИЯ КРИТИЧЕСКИХ СОСТОЯНИЙ У БОЛЬНЫХ ЭАГ» // Фундаментальные исследования. 2012. № 10-1. С. 103-107;
URL: https://fundamental-research.ru/en/article/view?id=30503 (дата обращения: 10.07.2026).