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NON-DRUG CORRECTION OF THE VEGETATIVE STATUS IN PATIENTS with ISCHEMIC heart failure

Pavlioukova E.N. 1 Rebrova T.Y. 2 Kuzmihkina M.A. 2 Afanasiev S.A. 2 Karpov R.S. 2
1 FSBI «Research Institute for Cardiology» of Siberian Branch under the Russian Academy of Medical Sciences, Tomsk
2 FSBI «Research Institute for Cardiology» of Siberian Branch under the Russian Academy of Medical Sciences, Tomsk
The assessment is carried out of possibility to use the course of aurikulyarny electrostimulation of the central kernels of n. vagus for correction of the vegetative status at ischemic heart failure. Manifestation of a sympathetic hyperactivity and condition of vegetative regulation were estimate by change of heart rate (HR) by 24 hours electrocardiogram monitoring. Condition of endogenic a stress – limiting systems in patients were estimated on presence of heart shock proteins (hsp70) which were defined by immunofermental method in lymphocytes of peripheral blood. Tolerable limit of drug – therapy, all patients had HR more than 60 beat/min, ejection fraction of left ventricle less than 40 % at the moment of inclusion in research. We didn’t reveal significant changes of patient clinical conditions after sham therapy. The new balance of a sympathetic and parasympathetic innervation was established at patients whom were performed course of auricular electrostimulation and it was expressive of reduced HR on a concurrent not changed drug therapy. Change of vegetative regulation of heart was conduced of sustentation of left ventricle myocardial functional due to of additional activation of endogenic stress-limiter systems of an organism. We found relation between reduce HR and increased level of hsp70. Conclusion, at chronic heart failure due to ischemic heart disease effective non-drug correction of the vegetative status is reached in that case when the organism of the patient keeps possibility to initiate in lymphocytes of peripheral blood additional synthesis hsp70 stress- proteins
chronic heart failure
heat shock proteins
stress proteins
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Рецензенты:

Ласукова Т.В., д.б.н., профессор кафедры медико-биологических дисциплин ФГБОУ ВПО «Томский государственный педагогический университет», г. Томск;

Матюшин Г.В., д.м.н., профессор, зав. кафедрой кардиологии и функциональной диагностики ГБОУ ВПО «КрасГМУ им. проф. В.Ф. Войно-Ясенецкого», г. Красноярск.

Работа поступила в редакцию 24.09.2012