Scientific journal
Fundamental research
ISSN 1812-7339
"Перечень" ВАК
ИФ РИНЦ = 1,674

Personal portfolio

THE OPTIMIZATION OF THERAPY FOR HERPETIC INFECTION IN PATIENTS WITH ATOPIC DERMATITIS

Barchatova T.S. 1 Shuldyakov A.A. 1
1 Saratov State Medical University n.a. V.I. Razumovsky, Saratov
In order to assess efficiency of cycloferon liniment in combined treatment for herpetic infection in patients with atopic dermatitis there was carried out an examination of 40 patients divided into two. In the first group the basic treatment was combined with cycloferon liniment applied twice a day within a 7-day period, while in the second group the treatment was implemented in compliance with standard guidance. It was proved that the use of cycloferon liniment in combination of therapeutic measures with patients with relapse of herpetic infection against the background of atopic dermatitis contribute the more dynamic disappearance of general infectious syndrome, reduces the duration of skin rash, of local inflammation, quickens the epithelization of erosions, lowers the frequency of relapses of infection in catamnesis.
herpes
atopic dermatitis
сycloferon
1. Barinskij J.F. Herpes: etiology, diagnosis and treatment. Moscow.: Medicine,1994. 342 p.
2. Ershov F.I. Antiviral drugs, 2nd edition. / F.I.Ershov. M.: Medicine, 2006. 237 p.
3. Isakov V.A., Kovalenko A.L., Krasnov V.V., Romantsov M.G., Rybalkina T.S. Therapy of various clinical manifestations of HSV disease / Clinical dermatology and venereology 2010. nо. 4. рр. 25–31.
4. Isakov V.A., Rybalkin S.B., Romantsov M.G. Herpes virus infection: Recommendations for physicians. St-Petersburg, 2006. 96p.
5. Nesterenko V.G., Begalo V.A., Lovenetsky A.N. The clinic, treatment and laboratory diagnosis of human disease herpesvirus // Manual for Physicians. M., 1998. 46 p.
6. Sobolev L.A., Shuldyakov A.A., Hlamova O.G., Romantsov M.G. Improved treatment of inflammatory diseases of the oral cavity / / Experimental and Clinical Pharmacology. 2011 № 8. P. 41–45.
7. Sologub T.M., Romantsov M.G., Rybalkina T.S., Rybalkin S.B., Smagina A.M., Isakov V.A., Kovalenko A.L. Modified therapy of herpetic infection / Clinical Medicine. 2011. nо. 3. рр. 54–57.
8. Beck L.A., Boguniewicz M, Hata T. et al. Phenotype of atopic dermatitis subjects with a his-tory of eczema herpeticum. J Allergy Clin Immunol. Aug 2009, 124 (2):260-9, 269.e1-7.
9. Birek l. C., Ficarra G. The diagnosis and management of oral herpes simplex infection / / Current Infectious Disease Reports. 2006, Vol. Eight. рр. 181–188.
10. Eisen D. The clinical characteristics of intraoral herpes simplex virus infection in 52 immu-nocompetent patients // Oral. Surg. Oral.Med. Oral. Pathol. Oral. Radiol. Endod., 1998. Vol. 86. рр. 432–437.
11. Lubbe J., Sanchez-Politta S., Tschanz C., Saurat J.H. Adults with atopic dermatitis and herpes simplex and topical therapy with tacrolimus: what kind of prevention?. Arch Dermatol. May 2003, 139(5):670-1.
12. Peng W.M., Jenneck C., Bussmann C. et al. Risk factors of atopic dermatitis patients for eczema herpeticum. J Invest Dermatol. May 2007;127(5):1261–3.
13. Wollenberg A., Zoch C. Wetzel S., Plewig G., Przybilla B. Predisposing factors and clinical features of eczema herpeticum: a retrospective analysis of 100 cases. J Am Acad Dermatol. Aug 2003, 49 (2) :198–205.

Рецензенты:

Моисеева И.Я., д.м.н., профессор, зав. кафедрой общей и клинической фармакологии медицинского института Пензенского государственного университета, г. Пенза;
Агеев И.С., д.м.н., профессор, зав. курсом клинической онкологии медицинского института Пензенского государственного университета, г. Пенза.
Работа поступила в редакцию 12.09.2012