Scientific journal
Fundamental research
ISSN 1812-7339
"Перечень" ВАК
ИФ РИНЦ = 1,674

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INFLUENCE of pharmacological compositions with transcutaneous activity oN hepatic metabolic adaptation DURING experimental burn trauma

Soloveva A.G. 1 Peretyagin S.P. 1 Zimin Y.V. 1 Martusevich A.K. 1 Larionova K.D. 1
1 Nizhny Novgorod Research Institute of Traumatology and Orthopaedy, Nizhny Novgorod
The aim of this work is investigation of influence of pharmacological compositions with transcutaneous activity on catalitic properties and regulation of oxydoreductases of rats liver at management of local and wide burns. Experiments were executed with 40 Wistar rats. Animals of first main group was burned locally (5 bsp), and rats of second main group got a wide burns (40 bsp). These main groups were divided at two subgroups, first of it was treated by «Levoxym» hel and second subgroup got a composition, including «Levoxym» amd «Tizol». Control groups included healthy and burned animals without treatment (n = 10 in each group). We estimated activitity of oxydoreductases (aldehyde dehydrogenase, lactate dehydrogenase and alcohol dehydrogenase) in rats liver homogenates. For investigation of specialties of indicated enzymes functioning we used balance indexes. It was stated, that use of combination «Tizol + Levoxym» is more effective as comparison with single «Levoxym» management. It is most demonstrative at wide experimental burns. So, local treatment with used composition with transcutaneous activity caused clear dynamics of catalytic and kinetic properties of liver oxydoreductases, which supplied metabolic adaptation of this organ.
liver oxydoreductases
metabolic adaptation
burn
tizol
levoxym
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Рецензенты:

Корягин А.С., д.б.н., профессор кафедры физиологии и биохимии человека и животных ГОУ ВПО «ННГУ им. Н.И. Лобачевского», г. Нижний Новгород;

Мухина И.В., д.б.н., профессор, заведующая кафедрой нормальной физиологии им. Н.Ю. Беленкова ГБОУ ВПО «Нижегородская государственная медицинская академия» МЗСР РФ, г. Нижний Новгород.