Scientific journal
Fundamental research
ISSN 1812-7339
"Перечень" ВАК
ИФ РИНЦ = 1,674

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HIRUDOTHERAPY EFFECT OF PLASMA HEMOSTASIS PARAMETERS IN PATIENTS WITH OR WITHOUT BRACHIOCEPHALIC ARTERIES THROMBUS OCCLUDING STENOSIS

Pospelova M.L. 1 Barnaulov O.D. 2
1 Сity advisory diagnostic center № 1, St. Petersburg
2 Bektereva Human Braun Institute, RAS St. Petersburg
The aim of the study – A clarification of the pathogenetic mechanisms of action and safety indicators development on coagulation parameters in hirudotherapy 154 cerebrovascular patients. Methods. Standard coagulation parameters were studied twice (before and after 2–2,5 months of the course hirudotherapy) in an open comparative randomized study in 31 patients with stenosis more than 75 % of internal carotid arteries (ICA) and not a comparative study in 123 patients without ICA stenosis. Results. The study noted that in all groups of patients initially normal coagulation parameters did not undergo significant changes, which confirms the safety and not mandatory laboratory monitoring of treatment. In groups of patients with ICA stenosis more than 75 % and without ICA stenosis the normalization of initially elevated levels of fibrinogen were detected. In some cases, patients with chronic vertebrobasilar insufficiency and hypertensive encephalopathy observed initial slow thrombin time, which accelerated and returned to normal after hirudotherapy. Conclusions. In general, the work shows miscellaneous changes the properties of blood in the hirudotherapy: the initial state of hypercoagulation contributed to the use of leeches activation of anticoagulation system (normalization of elevated fibrinogen), and the original hypocoagulation accompanied by an increase blood clotting (normalization extended thrombin time). Obviously corrective effect hirudotherapy, which increases the value of this method.
hirudotherapy
cerebrovascular disease
coagulogram
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Рецензенты:

Сорокумов В.А., д.м.н., профессор кафедры неврологии, Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова, г. Санкт-Петербург;

Бисага Г.Н., д.м.н., профессор кафедры неврологии ВМА им. С.М. Кирова, г. Санкт-Петербург.