Scientific journal
Fundamental research
ISSN 1812-7339
"Перечень" ВАК
ИФ РИНЦ = 1,674

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DISTURBANCE OF THE MAINTENANCE OF LIPIDS IN THE MEMBRANE OF RED BLOOD CELLS AT PATIENTS WITH VARIOUS GRAVITY OF CURRENT GESTOSIS

Miroshnichenko T.I. 1 Konoplya A.A. 1 Medvedeva I.N. 1 Bystrova N.A. 1
1 Kursk state medical university, Kursk
Now gestosis it is surveyed from positions of the syndrome of multiorgan insufficiency at the heart of which formation system inflammatory reaction which is characterised metabolic by disturbances lies. A research objective was definition of efficiency of standard treatment in correction of a lipide spectrum of membranes of erythrocytes at patients with gestosis various severity level. In work the data about imposing appearance changes of phospholipids and neutral lipids in the membrane of erythrocytes at patients with gestosis is presented various severity level. Disturbances of the lipide spectrum of membranes of red blood cells at patients with gestosis against standard therapy are established. Necessity including in standard therapy of patients with gestosis various severity level of membranoprotective the preparations including of essential phospholipids is defined.
gestosis
gravity of condition
membrane of erythrocytes
phospholipids
1. Ivanova O.J. Sostojanie vazoregulirujuwej funkcii jendotelija pri fiziologicheskom i oslozhnennom techenii beremennosti / Ivanova O.Ju., Gazazjan M.G., Ponomarjova N.A. // Kurskij nauchno-prakticheskij vestnik «Chelovek i ego zdorov’e». 2010. no. 4. рр. 67–72.
2. Konoplja A.I. Strukturno-funkcional’nye svojstva jeritrocitov v norme i pri patologii / A.I. Konoplja, L.G. Prokopenko, S.A. Dolgareva i dr. Kursk: Izd-vo KGMU, 2011. 192 p.
3. Krylov V.I. Metod tonkoslojnoj hromatografii lipidov membran jeritrocitov / V.I. Krylov, A.F. Vinogradov, S.I. Efremova // Lab. delo. 1984. no. 4. pp. 205–206.
4. Lakin, G.F. Biometrija / G.F. Lakin. M.: Vysshaja shkola, 1980. 243 p.
5. Lapina V.G. Prognosticheskoe znachenie opredelenija neopterina i provospalitel’nyh citokinov v kompleksnoj ocenke riska vozniknovenija gestoza / V.G. Lapina, T.S. Kachalina, N.Ju. Katkova // Medicinskij al’manah. 2010. no. 4 (13). pp. 103–104.
6. Medvinskij I.D. Sindrom sistemnogo vospalitel’nogo otveta pri gestoze / I.D. Medvinskij // Vestnik intensivnoj terapii. 2000. no. 1. pp. 21–24.
7. Sidorova I.S. Jendotelial’naja disfunkcija v razvitii gestoza / I.S. Sidorova, I.L. Galilova // Voprosy ginekologii, akusherstva i perinatologii. 2006. no. 1. pp. 75–81.
8. Strukturnaja organizacija membran jeritrocitov u beremennyh s gestozom / N.P. Mikaeljan, I.A. Knjazev, A.G. Maksina i dr. // Vestnik RAMN. 1997. no. 7. pp. 54–56.
9. Shishkina L.N. Lipidy jeritrocitov krovi i ih funkcional’naja aktivnost’ / L.N. Shishkina, O.G. Shevchenko // Uspehi sovremennoj biologii. 2010. T. 130, no. 6. pp. 587–602.
10. Beutler E. How do red cell enzymes age a new perspective / E. Beutler // Brit. J. Haemat. 1985. Vol. 61. pp. 377–384.
11. Dodge G.T. The preparation and chemical characteristics of hemoglobin free ghosts of human eryrhrocytes / G.T. Dodge, C. Mitchell, D.J. Hanahan // Arch. Biochem. Biophys. 1963. Vol. 100. pp. 119–130.
12. Ye X. Lysophospholipid signaling in the function and pathology of the reproductive system // Hum Reprod Update. 2008. Vol. 14(5). pp. 519–536.

Рецензенты:

Снимщикова И.А., д.м.н., профессор, заведующая кафедрой иммунологии и специализированных клинических дисциплин ФГБОУ ВПО «Орловский государственный университет», г. Орел;

Афанасьев Ю.И., д.м.н., профессор, заведующий кафедрой внутренних болезней № 1 ФГАОУ ВПО «Белгородский государственный национальный исследовательский университет», г. Белгород.

Работа поступила в редакцию 09.10.2012.