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IMPACT OF TREATMENT ON MEASURES OF IMMUNE INFLAMMATION ACTIVITY AND STRUCTURAL-FUNCTIONAL PROPERTIES OF VASCULATURE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Knyazeva L.I. 1 Okrachkova I.V. 1 Bondyreva A.V. 1 Knyazeva L.A. 1
1 Kursk State Medical University, Kursk
This article contains the results of research of serum levels of proinflammatory cytokines (IL-1в, IL-6, TNF-б), leptin, vasculature rigidity and elasticity measures in 60 patients with type 2 diabetes mellitus with obesity and 32 patients with type 2 diabetes mellitus and BMI < 25 kg/m2. The control group consisted of 24 persons without disorders of carbohydrate metabolism and obesity. Proinflammatory cytokinemia, hyperleptinemia, vasculature elasticity decrease and rigidity increase were determined in patients with type 2 diabetes mellitus, reaching their maximum in patients with obesity. It was found out that serum levels of IL-1в, IL-6, TNF-б and leptin were increased, while measures of structural-functional properties of arterial vasculature were changed in patients with type 2 diabetes mellitus with obesity. It was determined, that in addition to lipid-lowering effect, fenofibrate also has pleiotropic anti-inflammatory and vasoprotective activity.
proinflammatory cytokines
leptin
structural-functional properties of the vessel wall
fenofibrate
diabetes mellitus
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Рецензенты:

Ефремова О.А., д.м.н., зав. кафедрой внутренних болезней № 2 ФГАОУ ВПО «Белгородский государственный национальный исследовательский университет», г. Белгород;

Вишневский В.И., д.м.н., профессор, зав. кафедрой внутренних болезней медицинского института ФГБОУ ВПО «Орловский государственный университет», г. Орел.

Работа поступила в редакцию 24.07.2012.