Scientific journal
Fundamental research
ISSN 1812-7339
"Перечень" ВАК
ИФ РИНЦ = 1,674

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PHYSICAL AND CHEMICAL PROPERTIES OF SODIUM CHLORIDE SOLUTION AT ACTIVE OXYGEN AND NITROGEN EFFECT

Martusevich A.K. 1 Peretyagin S.P. 1 Ivannikova E.V. 2
1 Nizhny Novgorod Research Institute of Traumatology and Orthopaedy, Nizhny Novgorod
2 Nizhny Novgorod Regional Clinical Hospital, Nizhny Novgorod
We tested dynamics of some physical and chemical parameters (pH, oxidative and reductive potential, soluted oxygen level) of 0.9 % sodium choride solution at its barbotage by sources of reactive oxygen and nitrogen species (oxygen; ozone and oxygen mixture; oxygen, modified by d’arsonvalization; cold plasma, saturated by nitrogen oxide). Barbotage period for oxygen, modified by d’arsonvalization, was 1, 3 and 10 min, for nitroxylation – 1, 3 and 5 min. We used different ozone concentrations (1000, 5000 and 10000 mcg/l). Solution pH level and its oxidative and reductive potential were estimated by pH-meter «HI-8314». Temperature gradient and soluted oxygen level were tested on «Oxygenmeter ATT-3010» apparatus. It was stated, that solution oxygenation leads to reduce of oxidative and reductive potential with elevation of soluted oxygen level. Prevent oxygen processing by d’arsonvalization causes the increasing of solution oxidative and reductive potential. Ozonation induced dose-dependent stimulation of solution oxidative possibilities. Short (1-3 min) nitroxylation of sodium chloride solution leads to analogical (with ozonation and modified oxygenation) changes. Long (5 min) nitroxylation causes solution strong acidification with high growth of oxidative and reductive potential and soluted oxygen consumption.
nitrogen oxide
singlet oxygen
d’arsonvalization
pH
oxidative and reductive potential
solutions
1. Alekhina S.P., Scherbatyuk T.G. Ozonoterapija. Klinicheskie i jeksperimental’nye aspekty [Ozone therapy. Clinical and experimental aspects]. Nizhny Novgorod, 2003. 239 p.
2. Granik V.G., Grigorev N.B. Oksid azota (NO). Novyj putk poisku lekarstv [Nitrogen oxide (NO). A new way to medicine search]. Moscow, 2004. 360 p.
3. Zavorotnaya R.M., Ukrainskij revmatologicheskij zhurnal, 2002, no. 1, рp. 35–37.
4. Kostyuk V.A., Potapovich A.I. Bioradikaly i bioantioksidanty [Bioradicals and bioantioxidants]. Minsk, 2004. 174 p.
5. Lipatov K.B. et al., Hirurgija, 2002, no. 2, рp. 41–43.
6. Maslennikov O.V., Kontorschikova K.N. Ozonoterapija: Rukovodstvo dlja vrachej [Ozone therapy: Guidelines for doctors]. Nizhny Novgorod, 2008. 342 p.
7. Metelskaya V.A., Gumanova N.G., Klinicheskaja laboratornaja diagnostika, 2005, no. 6, рp. 15–18.
8. Peretyagin S.P., Struchkov A.A., Martusevich A.K. et al., Skoraja medicinskaja pomosch, 2011, vol. 12, no. 3, рp. 39–43.
9. Reutov V.P., Sorokina E.G., Ohotin V.E., Kositsin N.S. Ciklicheskie prevrascheniya oksida azota v organizme mlekopitayuschih [Ciclic transformations of nitrogen oxide in animals organism]. Moscow, 1998.
10. Samosyuk I.Z., Fisenko L.I. Singletno-kislorodnaya terapiya [Singlet oxygen therapy]. Kiev, 2007. 228 p.
11. Uzdenskiy A.B. Kletochno-molekulyarnye mehanizmy fotodinamicheskoy terapii [Cellular and molecular mechanisms of photodynamic therapy]. Moscow, 2010. 321 p.
12. Remizova M.I. et al. Effect of dinitrozyl iron complexes with glutathione on hemorrhagic shock followed by saline treatment // Eur. J. Pharmacol. 2011. Vol. 662. рр. 40–46.
13. Shekhter A.B. et al. Beneficial effect of gaseous nitric oxide on the healing of skin wounds // Nitric oxide. 2005. Vol. 12. рр. 210–219.
14. Vanin A.F. Dinitrosyl iron complexes with thiolate ligands: physico-chemistry, biochemistry and physiology // Nitric Oxide. 2009. Vol. 21. рр. 1–13.
15. Vanin A.F., Chazov E.I. Prospects of designing medicines with diverse therapeutic activity on the basis of dinitrosyl iron complexes with thiol-containing ligands // Biophysics. Vol. 56, nо. 2. рр. 268–275.

Рецензенты:

Жданова О.Б., д.б.н., доцент, зав. кафедрой гистологии, эмбриологии и цитологии ГОУ ВПО «Кировская государственная медицинская академия» МЗСР РФ, г. Киров;

Мухина И.В., д.б.н., профессор, зав. кафедрой нормальной физиологии им. Н.Ю. Беленкова ГБОУ ВПО «Нижегородская государственная медицинская академия» МЗСР РФ, г. Нижний Новгород;

Полещук О.Х., д.х.н., профессор, зав. кафедрой органической химии, Томский государственный педагогический университет Министерства науки и образования, г. Томск.

Работа поступила в редакцию 23.04.2012.