Known that acid lipoic, released by different companies-producers in the manner of tablet´s medicinal form possesses antioxidant, hypolipidemic, hypocholesterrinemic and desintoxicational actions. However is not excluded the manifestation to her and antiinflammatory action that allows the possibility of use of acid lipoic in external medicinal forms.
At development of external medicinal forms important role is conducted the nature the most carrier. So, in the last years as carriers of medicinal materials are used liposomes so making the external medicinal forms on base of liposoms gains broad spreading in production of unguents, helium, cream, jelly and balsams, make for high evacuation and efficiency of therapeutic action. The Insufficient assortment domestic antiinflammatory, regenerative preparations of external action with using vitamins promoted technology development of preparation 5% unguents with acid lipoic.
PURPOSE: Study reological characteristics of developed unguents, as well as revealing the factors, influencing upon realogical stability in process of long keeping of external medicinal form - unguents with acid lipoic.
METHODS: The Objects of study were shown the samples 5% unguents of acid lipoic on base "Lipex" (the lipid extract) with accompaniment aerosile in different concentrations.
Structured - mechanical characteristics of samples 5% unguents with acid lipoic study with use rotary viscosimetor "Reotest-2" (RV-2, Germany).
RESULTS: The Analysis of investigation samples of unguents with acid lipoic has shown that realogical of feature most high beside 5 % unguent with acid lipoic on base "Lipex" in contrast with the most base and will salve of acid lipoic with 1% aerosile.
Characterizing realogical of characteristic of samples of unguents follows to note that realogical of factor of under investigation samples of unguents with accompaniment aerosile in different concentrations different and increase with increase of its concentrations. Introduction acid lipoic right in base " Lipex " without accompaniment of auxiliary materials does not tell on change structured-mechanical characteristics.
To composition of unguents with acid lipoic of additional amount of oil phase (for instance, sunflower butter or butters of wild rose promotes reduction of importance of efficient viscosity in one and a half times nearly.
In process of research study the influence acid lipoic on viscosity of samples of unguents. So, is revealed that introduction of acid lipoic in base of unguents in amount 1 and 5 % from mass of unguents did not render any influences upon importance of efficient viscosity, as well as processes of structure form in system (the factor lg efficient viscosity and lg voltages of shift unguent bases.
CONCLUTION: Investigation defines samples of unguents with acid lipoic like high plastic bingamical systems.
Thereby, considered above factors, influencing upon structure form of unguents play the of no small importance role at study and forecasting of questions of biological accessibility of medicinal material - of acid lipoic from external medicinal forms - unguents in conditions in vivo and in vitro, as well as manifestations of specific activity and their stability.