Scientific journal
Fundamental research
ISSN 1812-7339
"Перечень" ВАК
ИФ РИНЦ = 1,798
ISSN 1812-7339
"Перечень" ВАК
ИФ РИНЦ = 1,798
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LIPID PEROXIDATION IN KIDNEY AFTER ISCHEMIA-REPERFUSION IN RATS WITH DIFFERENT RESISTANCE TO HYPOXIA
Bayburina G.A., Nurgaleeva E.A. 1, Shibkova D.Z. 2, Bashkatov S.A. 3
1 bashkir state medical university department of pahtophysiology
2 Chelyabinsk State Pedagogical University
3 Bashkir State University
4 KB
The aim of the work was to study the patterns of lipid peroxidation in the kidney in the long dynamics after ischemic damage caused by stopping general blood circulation of rats with different resistance to hypoxia. The experiment was performed on male noninbred albino rats, which were divided into 4 groups of resistance to hypoxia. 5-minute anoxia was simulated under general ether anesthesia by introtoracal vascular clamping beam of heart followed by resuscitation. The observation period was 35 days. In kidney tissue homogenates the content of the restored glutathione was determined, catalase, TBA-reactive products. It was found that the development and outcome of ischemic renal injury was caused by individual physiological and biochemical characteristics of animals. In high-stable and middle-stable rats initially high levels of antioxidant protection at relatively low activity of lipid peroxidation were observed. In animals unstable in deficiency of antioxidant defense high activity of lipid peroxidation was observed.
kidney
renal
hypoxia
ischemia
reperfusion
rats
lipid peroxidation
resistance to hypoxia
1. Bajburina G.A., Nurgaleeva E.A., Shibkova D.Z., Bashkatov S.A. Sposob opredelenija stepeni ustojchivosti k gipobaricheskoj gipoksii melkih laboratornyh zhivotnyh – Zajavka no. 20141377/14 s prioritetom ot 17.09.2014.
2. Zhirovoe pererozhdenie pecheni i ishemicheskaja bolezn’ serdca. Geriartricheskie aspekty [pod red. L.P. Horoshininoj]. M., 2014. 346 p.
3. Zhukova A.G., Sazontova T.G., Zarzheckij Ju.V., Volkov A.V., Moroz V.V. Tkanespecifichnost’ otveta sistemy pro-i antioksidantov posle reanimacii, Obshh. reanimatol., 2005, T. 1, no 3, pp. 46–53.
4. Zhukova A.G., Sazontova T.G., Ju.V. Arhipenko, Volkov A.V. Polovye razlichija v pro- i antioksidantnoj sistemah golovnogo mozga v otdalennom postreanimacionnom periode, Obshh. Reanimatol,. 2010, T. VI, no 4. pp. 54–57.
5. Zarubina I.V. Molekuljarnye mehanizmy individual’noj ustojchivosti k gipoksii, Obzory klin. farmakol. lek. Terapii, 2005, T. 4, no 1. pp. 49–51.
6. Meerson F.Z. Adaptacija k stressu i gipoksija, Bjull. jeksperim. biol. med., 1994, no 1, pp. 574–575.
7. Stal’naja I.D., Garishvili T.I. Opredelenie intensivnosti processov POL po urovnju malonovogo al’degida. Sovremennye metody v biohimii [pod red. V.N. Orehovichi]. Moscow, Medicina, 1997, pp 66–68.
8. Ahmadiasl N., Banaei S., Alihemmati A. Combination Antioxidant Effect of Erythropoietin and Melatonin on Renal Ischemia-Reperfusion Injury in Rats // Iran J. Basic Med. Sci. 2013. Vol. 16, no. 12. рр. 1209–1216.
9. Hueper K., Gutberlet M., Rong S., Hartung D., Mengel M., Lu X., Haller H., Wacker F., Meier M., Gueler F. Acute kidney injury: arterial spin labeling to monitor renal perfusion impairment in mice-comparison with histopathologic results and renal function // Radiology. 2014. Vol. 270, no. 1. рр. 117–24.
10. Lash L.H., Cummings B.S. Mechanisms of toxicant-induced acute kidney injury // Comprehensive Toxicology–Renal Toxicologyed. R.G. Schnellmann. Oxford: Elsevier, 2010. рр. 81–116.
11. Rodriguez F., Bonacasa B., Fenoy F.J., Salom M.G. Reactive oxygen and nitrogen species in the renal ischemia/reperfusion injury // Curr. Pharm. Des. 2013. Vol. 19, no. 15. рр. 2776–94.
12. Sabbahy E.M., Vaidya V.S. Ischemic kidney injury and mechanisms of tissue repair // Wiley Interdiscip Rev. Syst. Biol. Med. 2011. Vol. 3, no. 5. рр. 606–618.
Библиографическая ссылка
Байбурина Г.А., Нургалеева Е.А., Шибкова Д.З., Башкатов С.А. ПРОЦЕССЫ ЛИПОПЕРОКСИДАЦИИ В ПОЧКАХ ПОСЛЕ ИШЕМИИ-РЕПЕРФУЗИИ У КРЫС С РАЗЛИЧНОЙ УСТОЙЧИВОСТЬЮ К ГИПОКСИИ // Фундаментальные исследования. 2015. № 2-8. С. 1694-1698;URL: https://fundamental-research.ru/en/article/view?id=37254 (дата обращения: 25.06.2026).