Scientific journal
Fundamental research
ISSN 1812-7339
"Перечень" ВАК
ИФ РИНЦ = 1,798

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SYNTHESIS AND BIOLOGICAL ACTIVITY QUINOLINE-2-CARBOXAMIDES

Boyarshinov V.D 1, Mikhalev A.I 1, Yushkova T.A 1, Konshina T.A 1, Ukhov S.V 1,
1 Perm State Pharmaceutical Academy
According to the literature data derivatives of quinoline-2-carboxylic acid include compounds exhibiting a different biological activity. In this work, substituted quinoline-2-carboxylic acid amides were synthesized in good yields by the reaction of the methyl quinoline-2-carboxylate with amines in ethylene glycol at 170–180 °C and quinoline-2-carboxylic (quinaldinic) acid chloride with amines in benzene at 50 °C. The structures of received compounds have been determined on the basic NMR 1H spectral data. Purity of the synthesized compounds was confirmed by thin layer chromatography data. Physico-chemical properties of the final products were determined. In animal studies, was determined anti-inflammatory and analgesic activity compared to standard drug: diclofenac sodium. Developed technique of synthesis of quinoline -2-carboxylic acids amides can be used in preparative organic chemistry for obtaining bioactive substances potentially quinoline series.
quinoline-2-carboxylic acid
quinoline-2-carboxamides
anti-inflammatory
analgesic activity.
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Библиографическая ссылка

Бояршинов В.Д., Михалев А.И., Юшкова Т.А., Коньшина Т.А., Ухов С.В., СИНТЕЗ И БИОЛОГИЧЕСКАЯ АКТИВНОСТЬ ХИНОЛИН-2-КАРБОКСАМИДОВ // Фундаментальные исследования. 2015. № 2-8. С. 1715-1719;
URL: https://fundamental-research.ru/en/article/view?id=37218 (дата обращения: 25.06.2026).