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Fundamental research
ISSN 1812-7339
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THE ANTIOXIDANT PROPERTIES OF STABILIZED AQUEOUS LIVER EXTRACT SPINY DOGFISH (SQUALUS ACANTHIAS) IN CONDITIONS OF APPLICATION OF CYTOSTATIC

Batagova F.E. 1, 2, Batagova F.E 1, Albegova S.K 1, 2, Skupnevsky S.V 1
1 North Ossetian State Medical Academy
2 Institute of Biomedical Research of Vladikavkaz scientific center of the Russian Academy of Sciences and Government of the Republic of North Ossetia-Alania
The antioxidant properties of stabilized aqueous extract isolated from shark liver (Squalus acanthias) – «Squaacan» are studied on Male Wistar rats (40) were divided in four groups: control, group with model pathology (oxidative stress created by the injection of Cyclophosphamide), group with «Squaacan» only and alternation of Cyclophosphamide / «Squaacan». In conditions of hyper lipid peroxidation caused by introduction of cyclophosphamide the results of experiments showed that the extract has a pronounced antiradical effect, which manifests itself in reducing the formation of lipid peroxidation products (hydroperoxides and malondialdehyde), decreasing in hepato-specific enzyme activity (ALT&AST) and increasing of membrane’s resistance to solutions with high hypertonic effect. While the catalase activity in all studied groups remains unchanged. Thus, it can be assumed that «Squaacan» has a pronounced antiradical and membrane stabilizing effects.
antioxidant
hydroperoxide
catalase
spiny dogfish
malondialdehyde
lipid peroxidation
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Библиографическая ссылка

Батагова Ф.Э., Албегова Ж.С., Скупневский С.В., Джиоев И.Г. АНТИОКСИДАНТНЫЕ СВОЙСТВА СТАБИЛИЗИРОВАННОГО ВОДНОГО ЭКСТРАКТА ПЕЧЕНИ КОЛЮЧЕЙ АКУЛЫ (Squalus acanthias) В УСЛОВИЯХ ПРИМЕНЕНИЯ ЦИТОСТАТИКА // Фундаментальные исследования. 2014. № 10-10. С. 1897-1901;
URL: https://fundamental-research.ru/en/article/view?id=36648 (дата обращения: 06.07.2026).