Lithium carbonate is used for correcting some hereditary and gained neutropenias, in particular, at leykocytopenia at оncologist´s patients after radiotherapy however its using not always effectively and is accompanied side effects. Organic ligands allow vastly to reduce toxicity of metals, as well as modulate their biological action. The role of separate amino acids in process hematopoiesis is noted and all this defines actuality of searching of potential stimulatories of hematopoiesis among complexes compounds of lithium with amino acids.
PURPOSE: The aim of our investigation was study the influence of a new amino acid complex of lithium on hemopoiesis at rats, which were exposed by total-body irradiation. The compound was created in chimical laboratory of Kasan State University
METHODS:The estimation an effect of new compound realized on model a total-body irradiation of rats, caused by total-body gamma-irradiation in dose 4,5 Gy on installation AGAT-R1. The rats has been receiving lithium intraperitoneal in dose 15 mg/kg since the third day after irradiation. The condition a hemopoiesis value on indexes of blood, hemotopoietic marrow at rats in control group and experimental group before and after treatment. The results were processed statistical, using t criterion Student.
RESULTS: Results demonstrated that the treatment compound lithium accelerated post-irradiation recovery of hematopoietic marrow and corrected the indexes of blood at rats in experiment. Discovered increase the amount of monocytes in the treatment with new amino acid complex lithium post-irradiation, allows to expect that effect of compound realizes through interleukin-2, granulocyte-macrophage-colony-stimulating factor, selected macrophages or monocytes of microenvironment of bone-marrow, since they in sufficient degrees resistent to action of irradiation. Efficient recovery erythropoesis in using the new compound of lithium can be explained as well as ability an to macrophages synthesize erythropoietin. New amino acid complex lithium shows pharmocological action after post-irradiation oppression hemopoiesis in total dose, corresponding 1/17 DL50 then as of literature, lithium carbonate - in DL50 , but lithium sucsynate - in 2/5 DL50.
COUNCLUTION: Thereby, new amino acid complex lithium corrigens the syndrome post-irradiation myelosuppression at rats.
Библиографическая ссылка
Zaljalutdinova L.N., Khafizianova R.H., Bakirova N.E., Jadukov O.A., Imanaev R.M., Imanaev I. R. THE STUDY OF INFLUENCE OF NEW AMINOACID COMPLEX OF LITHIUM ON POST-IRRADIATION REGENERATION OF HEMOPOIESIS IN EXPERIMENT // Фундаментальные исследования. – 2005. – № 8. – С. 34-35;URL: https://fundamental-research.ru/ru/article/view?id=6428 (дата обращения: 16.08.2024).